Are there any issues with connecting speaker wire in this manner?

make the loop fit tightly on the screw and orient it so that tightening the screw pulls the wire in rather than pushes it out.  if done correctly, this is an excellent connection.  

This is what I do with the 12-gauge single-conductor speaker wire I have running to my Maggies from my amp.  I have gotten in the habit or periodically reaching behind the amp to check the connection tightness.  Every few months there is a tiny, tiny bit of tightening that can be done.  I don't believe I ever come close to losing signal.  An occasional spray of CRC QD electronic cleaning spray doesn't hurt, either.  My listening room opens to the kitchen on one long side - and we cook.  A lot.  You'd be amazed at what a little electrical douching will do for SQ in such an environment.

@lcherepkai

Unless you’re willing to modify the chassis, run raw speaker cable internally, and direct solder to the exit points of the output stages, you’re going to be dealing some compromise in SQ. Each termination point introduces an additional "relay," contact point, inferior material, etc. into the signal path. But, us "consumers" want the convenience and flexibility of connecting things "easily."

While there is nothing "wrong" about connecting raw cable to speaker terminals, it’s not very convenient to do so, but certainly more convenient that direct soldering internally. And, depending on the number of predicted connect/disconnect events you see in your future, a direct connection (to the speaker terminals) may, in fact, be the most efficient connection method. The time spent terminating a cable so that it will be convenient to disconnect/reconnect later may be more time (and money) consuming than just connecting the cables directly IF you don’t foresee the need to move the cables for any reason.

@ktarver

"Why on god green earth would anyone run solid conductors for cables that transmit frequencies?"

It’s been know for some time that "skin effect" becomes a non-factor at a given cable diameter. Well-designed "solid core" cables can pass signals greater than 20kHz. In theory, ALL cables are "solid core". Some are just smaller than others. Even most miniscule cables have "solid cores." The differentiator is that "stranded" cables have muliple smaller cables grouped together to form a single larger gauge cable, and "solid core" cables have conductors that are individually insulated, thus not "talking to each other" until the sound arrives at the other end.

We can debate the pros and cons of the sonic attributes of "stranded" vs "solid core" (and, have for decades). The "skin effect" factor of well-designed cables is not one of them.

I've yet to see anyone run the numbers on skin effect on speaker cables and show a significant difference in audio frequencies.

waytoomuchstuff:  thank you for responding to ktarver's post.  I had wanted to but just couldn't get motivated.  As to your 1st response, I've been using speaker cable that is 7 solid core 18awg silver plated copper wires per leg without termination for years.  The Red Dragon S-500's are the first amps I've used without the center pin drilled for bare wire.  The wire is big enough that it fits nicely as if they were banana plugs.  It's not a tight fit, just snug, but that's what I've been doing ever since I received the Red Dragon amps.  I never move speaker cables unless I am forced to move the speakers.  I was one of those fools that spent big bucks (back then) to get the huge Monster Cables banana plugs and, soundwise, they sucked!  That's when I discovered less can be more in audio.  Thanks!