Best multi channel amp and processor good for 2 channel listening.

@maguair, the Marantz is meant to be left on and used for extended periods of time, so won’t be a problem. If you plan on putting it in an enclosed cabinet, then you should get the inexpensive AC Inifnity Aircom fan unit to put on top. That should be used with any component in an enclosed space, including the other processors or amps you are looking at. But with enough clearance and air flow I wouldn’t worry about it. It may not be any hotter than the other processors, I have not compared. My older Denon x6400H receiver ran far hotter and I would leave it one for extended periods of time and never had an issue.

You would need a multi-channel amp as well to drive your other speakers (center and surrounds). The pre/pro has analog audio which feeds to your integrated for the front L/R two speakers, and the other channel outputs to another amp (or amps) to drive any other speakers.

edit:  just noticed @dep14’s post, you can definitely just pick up a higher end Marantz or Denon receiver to drive the rest of your home theater speakers. You would just use the pre-out for the L/R to the integrated.  However, just make sure your speakers are easy to drive.

Just a comment.  maguair is coming from a Krell S1000 as a processor.  I have tested the Marant 8805 in my system and compared it to my Krell S1200U.  The Marantz is a very good device with excellent bass and midrange impact.  Full and natural sound.  However, it is voiced warm and the high frequencies are softened and rolled-off.  It is very excellent sound, but it could end up being too "dull" sounding for you, unless you want this type of signature.

@auxinput makes a great point, it’s a matter of taste.  As an example, if you compare Denon with Marantz, they share similar components but the Denon is voiced on the brighter side compared to Marantz.  Major difference, other than the sound signature, is that the Marantz is well regarded for having their HDAM analog output stages for the pre outs.

@maguair if you decide to go down the receiver route, Denon’s flagship X8500H is one to look at as well.  That is one amazing receiver for the price.  I had the X6400H and it was fantastic, the X8500H is another level from that.

@maguiar

So, unless your center, surrounds, and atmos (if you go that way) are hard to drive - the easiest solution is probably a really nice integrated amp, and a surround receiver to do your surround processing, and drive everything but your 2 channel.

An integrated with a built-in DAC could even simplify streaming.

I have a Marantz 8802 processor, but it does require outside amps to drive my center and rears. (I’m only running 5.1). I currently have a Mark Levinson 585 driving my 2 channel. (I also have pass labs separates I am selling as the 585 is really good). I’ll be using the built-in DAC to take my streamer signal and that makes things even easier.

That said, if I did it over today I would probably just do a higher end receiver and a nice integrated to simplify further. The nicer 2 channel integrated amps have really surprised me with how good they sound for 2 channel.

That said, if the budget is 22k... you have all sorts of options.  My biggest question is actually - how much space, shelves, etc do you have and want to use.

The larger companies have one huge advantage I've found and that is in the HDMI switching/pass through market, along with having the latest surround chips.  Their stuff works.  The higher end stuff DOES sound a bit better particularly for 2 channel (if your SSP is going to do 2 channel), but lord knows they almost all seem to have HDMI switching issues/lag/boards going out, or are a bit behind on the surround processing.  Surround formats and HDMI etc change so quickly it's hard to have a solution that is cost effective if you want to have the latest and greatest.

But... how many "boxes" do you want and how much space?  

wow, one of the best discussions I've read in a long time on any forum. Civil, very informative and lots of expertise/ experience.      

I'm using a "vintage" Marantz Sr6003 (soon to be replaced by a SR8012 or 8805 lol  thinking, thinking ) in my system as a preamp to the front three, and bi-amping off of a six channel Krell S1500. I've tried Bryston, Sunfire (rebuilt 5 x200), Carver and Parasound amps before settling on the Krell. The SR powers the sides and rear speakers in a 7.2 configuration. Using KEF Reference 5s (bought new/used for a great price )  and 4C for the fronts, Q900 sides (use to be the fronts) and Q800d for rear (which must be rewired to work correctly BTW) .System is used 40% for music. Truly sounds amazing IMHO and to all of those of all that have heard it. And much better than systems I've heard that have cost more. The S1500 never runs out of steam and suits my tastes for speed, articulation, and clarity just perfectly. That being said, the S1500 is very honest in that it presents everything upstream as they are... it doesn't hide weak links of which I still have a few lol But I'm working on it! I have a second surround system 7.1 in my mancave (75% music) powered by a Marantz 6007 and the Sunfire 5 x 200.The Marantz have been very dependable, are very musical,have great voicing for TV / movies, offer excellent switching, easy menus but are neither warm sounding nor clinical.