I've spent a good portion of the past 5 days listening and swapping the D'Agostino S-250 with Ayre MX-R Twenties in my system. The following is what I hear.
The associated system is a Berkeley Alpha Reference 2 processor feeding the amps directly or thru an Ayre KX-R Twenty preamp. Interconnects are Audioquest WEL Signature or Synergistic Research Element CTS. Speakers driven are Wilson Alexia's and cables are Synergistic Research Galileo LE.
First let me say the Ayre and D'Agostino amps are more similar than different. They are more similar than Audio Research, Pass Labs, Atma Sphere, Krell, all of which I've heard in my system. So their differences are quite small. That said, they are not the same, but differ throughout their presentation.
In the bass, the D'Agostino amp is both meaty and exercises control in the low frequencies. The Ayre is a little more resonant and wooly. Advantage D'Agostino.
In the essential mids, the Ayre amps give an illusion of speed and clarity. The S-250 is richer and fuller. The Ayre images clearly interact within the speaker plane. The D'Agostino amp engulfs the listening arena. My wife made a solid comment. She said the S-250 is rich without being murky.
In the highs, I thought piano thru the Ayre's was the best solid state treble I'd heard. Until I heard the D'Agostino. Its richness extends into the highs with a purity and wholeness.
One system concern with the highs. The Wilson speaker does not accentuate the highs and neither does the S-250. Combine that with the Spectacular Galileo LE's which also tip toward darkness, and the highs sounded a little subdued. I substituted a set of 7.9 ohm tweeter resistors for the stock 9 ohm set, which should increase the tweeter output by about .5-.6 db. Perfect. The sparkle in the highs returned with flawless integration with the mids.
When I think Ayre, I think clarity, speed, resolution. When I think D'Agostino, I think musical integration.
So, the verdict, to me, in my system, is that I prefer the harmonic richness and overall musicality of the D'Agostino S-250. I also found no channel separation issues that would make me wish for mono amplifiers.
One negative of the S-250 being a stereo amplifier, is the lack of space on the rear to accommodate large, thick audiophile cables, interconnects, and a power cord. I made it work, but it wasn't easy.