When I ran my MC cable I used metal boxes for the outlets so that the MC cable jacket is attached to the metal outlet box and the metal case of the breaker box. I believe the metal casing of the breaker box is grounded. I did not know that the MC cable was twisted but I am glad to know that it is.
Our neighborhood has underground utilities and I share a transformer with one neighbor. Our house is 23 years old. I brought home an AQ Niagara 5000 Power Conditioner from my local store (140 miles away) to try out. I did not take it back. Whatever magic is inside of it, it makes the sound better. Not sure if it has an Isolation transformer. The addition of good power cords improved the blackness of the sound as well.
I have a vacuum tube preamp and I hear no noise with my ear to the tweeters. My phono preamp generates a little tube rush noise that can be heard close to the tweeters; but that is to be expected with 66 dB of gain. (Moving Coil preamp)