Does it pay to upgrade tubes in power supply of preamp??


Hi- Just got a Canary Audio C1600 preamp= As my title states is there any significant change in sound when upgrading power supply tubes- the tubes are- (1)GZ34, (2) 6V6 and (1) 6SL7
If so any suggestions would be appreciated
The main unit uses 4- 6sn7 tubes- I know there are a ton of 6sn7 examples - has anyone upgraded the tubes in this preamp and if so any suggestions-
Also got the Canary M-350 amps- which use 4-300b per amp and 2- 6sn7's per amp- any thoughts on tube upgrades for these- as 8 300b;s will run a boat load of $$$$- 
thanks and Happy holidays!!
bopper
Changing and trying different tubes in the power supply would certainly effect the sound or flavor of the presentation. That rectifier tube would probably have the biggest effect, so start there.
That rectifier tube would probably have the biggest effect, so start there.

Yup.
Get some vintage RCA or Philips JAN (military spec) tubes. They will be far superior to whatever Chinese or Russian tubes may be in it now. These are not really that expensive either. But don't diddle; these won't be made again.
I would expect the 6V6 and 6SL7 to have more effect.

The 6V6 is the pass regulator tube. The 6SL7 is the voltage feedback tube and controls the 6V6. So you can see that both would have a greater effect than the rectifier, which is upstream from both of these tubes. Essentially the voltage from the rectifier has to pass through the 6V6 to be regulated before getting to the preamp itself. The output of the rectifier is a sawtooth waveform that is smoothed by filter capacitors; after the 6V6 regulator there should be no sawtooth waveform present in any quantity at all.
Replacing any tubes can have an effect upon the sound if I was you I would contact Brent Jesse as he has  a lot of knowledge and can steer you in the right direction all the best