Dog pissed on speaker

Only one person suggest an ozone generator.  Least likely to damage the components. That would eventually break down the uric acid, urea, and other nittrogenous compounds generating the ammoniacal smell after bacteria and enzyme exposure. UV light (germicidal) might work, but don't expose paper to it (no speaker cones) only the box.

Jeez, just replace the driver. Quick search showed OEM driver is under 150 $. I wouldn't think twice.

Actually the suggestion of taking the driver out and putting it outside in sunlight is not bad, it would help break down the urine, albeit it might also help break down the cone. Ozone generator similar idea but it's an open question about how good of an idea that is in your house.  

But if it were my speaker, I'd replace the driver. The thought would drive me nuts regardless of the actual impact or lack thereof. 

Ozone generators I believe work well on lingering bad odors.