Look, no one would put a switch box in the signal path for no reason. But if you need to compare gear it’s a much better way than powering up and down and swapping cables.
This is the only reason I would put a switch box in -- to try to make a comparison. Then, I’d set it aside. Regarding
@b_limo point about variables — the idea would be to use the same cable and keep the other elements as similar as possible (positioning, room, etc.) It might be necessary to quickly move the speaker being auditioned around a bit — but that can be quickly done, compared to the amp on and off rigamarole.
Of course, if the switch box isn’t high quality, then I could be degrading the sound too much for both speakers and erasing important details which would be crucial to their character — and their difference.
It seems this is another debate that rests upon empirical details not fully definite -- which speakers, which switch box, etc. I don't have the speakers yet, so this is impossible to detail, yet. I'm trying to decide on buying a switch box.
Another option is for me to get a switch box and try both. If I hear no degradation of sound with the switch box on either speaker, I can go ahead and compare them.