Cabinet resonances are easier (less expensive) to tame in small speakers, so that can be a factor when comparing monitors and towers in the same line, especially at lower price-points. With proper attention, resonances can be adequately addressed regardless of speaker size.
I do think proper subwoofer integration is beneficial regardless of the main loudspeaker's bandwidth because the best placement for soundstage and imaging is rarely also the best place for low and sub bass wave launch. The ability to optimize these concerns independently is advantageous to achieving the best setup.
Personally, I had a pair of Legacy Audio FOCUS SE towers in a 19 x 21 ft room with a 10 ft ceiling. They worked very well there, but when I moved from the east to west coast (USA), I could not afford a listening room of that size. Cramming them into the new 15.5 x 10.1 ft room with 8 ft ceiling simply did not work, no matter what I did with room treatments. I could not get my ears far enough away from those six drivers for them to seamlessly integrate. Wonderful speakers, but they sounded like stadium speakers in my small room compared to a good 2-way monitor, like the Fritz Carrera 7 BE.
Again, lesson learned…give the room what it wants, and it will treat you right.