No, they are OK. Actually, I had an upgraded fuse (the main, external fuse), and it was taken out by a defective tube. You might have seen my thread a while back. Replaced the tube and used a generic fuse and all is working ok.
Now I'm in the process of getting a quad of new tubes, replace the fuse that went, and thought it was the right time to consider upgrading other fuses, should there be any more, should they make a difference, and should it not require disassembling the whole amp to do so.
Can you elaborate on you first post, dude?