Very sad to hear your story, but a two-year prognosis at least offers *some* hope. Even if medicine has done all it can do, spontaneous regressions/remissions do happen. They’re rare of course, but not non-existent. Either way I wish you all the very best.
In terms of the actual question, I did the same thing a couple of years back. Very willingly in my case though, as I was simply tired of owning a monstrous system.
After a god-awful lot of auditioning here, there and everywhere I now listen to a Luxman L-550AXII and a pair of Tannoy Legacy Eatons. As far as I’m concerned it’s a perfect pairing and I’m happier with the sound here than I’ve ever been. Depending on the size of the room you might want to look at the Eatons two bigger brothers, Cheviot and Arden. That said the Eatons can fill a much larger space than the 30m2 room I use them in.
To my ears the Luxman is simply sublime and it has an abundance of power in terms of what either of the Legacy models require. I also considered and auditioned the 590AXII, but as didn’t find it to sound any better I decided against it. Equally excellent of course and no doubt better than the 550AXII on more demanding loads, but only a pointless extra expense in my case.
Whatever you end up with, here’s hoping your down-size will do for you what mine did for me!