I assumed I'd set up the speakers on the narrow end
I think that with your size room it would be better to place your speakers along the 11' wall. This will allow you to place both your speakers and your listening chair closer to the center of the room and away from the walls. You should try and keep a few feet if possible between your chair and the wall behind it.
The room will always be your biggest obstacle in achieving great sound. I would put most of my energy into learning how to either tune your room to your system (room treatments) or tune your system to your room (equalization) or a combination of both.
My room is 14' 4" x 10' 6" x 9'. I'm pairing small bookshelf speakers with 4) 12" subs. I play very loud aggressive music and I feel the highs are very clear and distinct, the mids are warm and natural and the lows thump but are not boomy.