You didn't tell us what type of music you would listen to on this system. Classic rock. vocals, jazz, small classical, large classical, techno...? I always have a small system (not desktop speakers) in my 10'x13' office. I have usually used gear that I has been lying around.
If I was going to do it again from scratch, I would stick to tubes and use the decware Zen Mini Torii tube amp or an Linear Tube Audio MZ2. For speakers I would use a pair of Omega Super 3i monitor speakers or maybe the decware DM945 bookshelf speakers. The Omegas are rear-ported but Louis can build you a pair with the ports on the front.
Any combination of these components can be had for under $2K. It would be hard to find better sound at this price, IMO.