The easiest way to check if the problem is coming from the room, is to just try the system in different room and see if you get the same results. Then you'll know for sure. If it does sound the same, I would try swapping out your components one at a time. If your problem is with one of your components, you're likely to find the one causing the problem.
If you still feel it may be the room, rotate your system 45 degrees. (Your listening chair will be pointed directly at a corner.)
If you still feel it may be the room, rotate your system 45 degrees. (Your listening chair will be pointed directly at a corner.)