What sends shivers down your spine when you play it on your system?

“The Ecstasy of Gold” orchestral intro on Metallica’s “S&M” CD. 
Beatles- Nowhere Man (the combination of harmony vocals, soaring fluid bass lines and dual guitar solo played by John & George just blows me away every time)
John Denver- Back Home Again
Led Zeppelin- When The Levee Breaks
David Bowie- Suffragette City
Rush- Entre Nous
Uriah Heep- The Wizard
Deep Purple- Burn
Lynyrd Skynyrd- Gimme Back My Bullets 
Mahler 1-5 symphonies
Moussorgsky/Ravel - Pictures at an Exhibition, Chicago/Giulini
Vaughn Williams - Fantasia on a theme by Thomas Tallis, ASMF/Marriner
Huey Lewis and the News - The Heart of Rock n Roll
Handel - Messiah, Hallelujah chorus
Barber - Adagio for Strings
Cherubini - Requiem
Beatles - Abbey Road
Satie - Gnossiennes, Gymnopiedes
Pentatonix - Mary Did You Know?
Stravinsky - Rite of Spring
Big Phat Band - Sing, Sang, Sung on Swinging for the Fences
Bach Cello Suites - Janos Starker

Off the top of my head ... :)
Fantastic songs with fantastic guitar (youtube)

Phil Collins - First of frith (live)

Derek Trucks Band - Midnight in Harlem (live)

John Mayer - Gravity (live)
Some jazz for some educated soul:

Shivers on my spine indeed....

Kenny Wheeler :  The widow on the window

Supremum artistry akin to any of the best jazz album there is....