Congratulations. Sounds like a great move. Over the last five years I helped a friend that realized he wanted to finally get into high end audio in advance of retiring. He is now about your age and very happy.
First. your room sounds great. It is not an issue. Over time you can treat it to get the best out of it.
I recommend your first step is to set a direction. I would take your time on this. Consider what you have now as your reference system. You want to experience the spectrum of sound types and find what you want in the long run. As we get older, we learn more about sound and I think for most of us we gravitate to a system that communicates a deeper emotional connection with music. More so than the loud and bass heavy dynamic of our youth. So, don’t put too much emphasis on what you remember.
Go to a dealer and find a few audiophiles in your area. Listen to the best they have... and you want to hear contrast with your system. There is high impact ( the muscle car of systems) like B&W / MacIntosh, highly detailed fast Magico / Boulder... there are natural musical systems like Sonus Faber speakers / Audio Research and all sorts of systems in between. You want to listen to really good ones in each category. See what you are really attracted to... careful... highly detailed / impactful systems can be fatiguing and not musical. Then later you worry about what you can afford. Maybe travel to listen. You want a direction... then you can start swapping equipment.
Just a note. I am 73 and been pursuing this for over fifty years. You can see where I landed under my user ID. I slowly gravitated to more musical / natural sounding tubed equipment and speakers. Not an uncommon destination for mature folks. To help, what kind of car do you own? If it is a corvette... then look at B&W / MacIntosh... I have a Lexus... so for me Audio Research Sonus Faber. Porche... different system... Subaru Outback... different. The sound you like is typically a reflection of your personality.