as far as hurting anything goes the 5751 and any of the 12-7 are drop and play just as Mechans says. These changes may affect how things sound however. In guitar amps the pre amp tubes, especially the first gain stage are often swapped out to affect how much clean headroom the amp has before breakup. the lower gain preamp tubes hit the power section easier and give you more head room. due to power section design in a hi fi amp breakup probably isn't and issue