The synergy is built into the loudspeaker and the audiophile doesn’t have to search for some magical pairing of loudspeaker and amplifier. Active loudspeakers definitely have the potential for better sound compared to passive designs.
Whose synergy? The designers?
The reason audiophiles use separates is to create their personal synergy that works best with their tastes and the sound of their particular room. Audiophiles generally do not want Genelecs or Kii 3, despite their brilliant measured nearfield response in an anechoic chamber.