This construct of "which do you prefer, XLR or RCA cables" is kind of backwards. Choice of XLR vs RCA (single ended) cables follows the design of source equipment such as DACs & preamps, in which either balanced or single ended designs may be executed for reasons best known to the designer.
I have 2 balanced headphone amps in my system (which also sport SE outputs); and 4-5 single ended headphone amps; and a big speaker amp that can be run via SE or balanced cables. So I've had a lot of chances to compare SE vs balanced, across amps. Here's what I've observed:
-- Running an all balanced system (source components & preamp & speaker or headphone amps all designed for balanced operation) might be ideal theoretically. But due to the greater output voltage coming from balanced vs SE source components (2.0V - ~3.0V SE vs 4.0V - ~5.0V balanced), a balanced chain would introduce intolerable gain issues that are not possible to eradicate without introducing ancillary gear (ie, passive volume controller) in one or more places to control gain (and that's hardly ideal).
-- Headphone amps designed for balanced operation usually sound better via balanced output cable to the headphone vs single-ended cables. Headphones are quite revealing and these differences, though subtle, are not a big challenge to hear. Balanced cables often deliver slightly better/wider/deeper soundstage, dynamics, and bass.
Having said all that--if I ran a music studio and my audio gear was in service of music production, everything would be balanced--because long runs of balanced cabling are far more immune to RFI and other external distortions than single ended cabling.
I have 2 balanced headphone amps in my system (which also sport SE outputs); and 4-5 single ended headphone amps; and a big speaker amp that can be run via SE or balanced cables. So I've had a lot of chances to compare SE vs balanced, across amps. Here's what I've observed:
-- Running an all balanced system (source components & preamp & speaker or headphone amps all designed for balanced operation) might be ideal theoretically. But due to the greater output voltage coming from balanced vs SE source components (2.0V - ~3.0V SE vs 4.0V - ~5.0V balanced), a balanced chain would introduce intolerable gain issues that are not possible to eradicate without introducing ancillary gear (ie, passive volume controller) in one or more places to control gain (and that's hardly ideal).
-- Headphone amps designed for balanced operation usually sound better via balanced output cable to the headphone vs single-ended cables. Headphones are quite revealing and these differences, though subtle, are not a big challenge to hear. Balanced cables often deliver slightly better/wider/deeper soundstage, dynamics, and bass.
Having said all that--if I ran a music studio and my audio gear was in service of music production, everything would be balanced--because long runs of balanced cabling are far more immune to RFI and other external distortions than single ended cabling.