I’ve always found power tubes more important to shaping the sound in ways that are meaningful to me. Small tubes can also be important to be sure, but a lot of times it’s an initial "wow!" impression, then over time I either tire of that variant or just want to hear a different flavor. I listen loud (more strain on power tubes), so perhaps that explains my findings.
With power tubes, my initial impressions tend to stick. The change from a KT88 to KT120 is especially significant in amps where I’ve tried this swap. Anyways, what’s your tube amp that has 16 freaking KT88 slots to replace with a non-existent Siemens 6550? (I know op won’t answer) To be fair, if the Siemens 6550 did exist, I’d prefer it over JJ.
I actually have a pair of VAC Master 300 that use 16 KT88 (plus 8 6SN7), and even with auto bias it’s a kind of a PITA to swap. The KT120 sound great here, too.