I highly recommend going with stereo subs. My experience are with the REL Stadium IIIs. I started with a single and added the second sub within 2 months. As best as I can describe it, the sound of the system "relaxed" with the added sub. It's a subtle difference, but one that I find well worth the expense. Integrating the second sub wasn't twice as hard as a single sub, but it's at least 1.5x.
My room is 31' by 14.5' and the main speakers are M-L Odyessey.
My room is 31' by 14.5' and the main speakers are M-L Odyessey.