It does make an audible difference for sure. Without the bi-wiring, to my ears the same content, particularly the mids, sounded more forward and noticeably disjointed from the rest of the music. As soon as I removed the jumpers and plugged the second set of cables everything sort of smoothed out. I have a similar (bi-wire) set up with different amps on my Martin Logans and the difference was not anywhere as noticeable. Of course everything between the two systems are different including the listening room so it may not be apples to apples comparison. Just one more data point.