Can the digital "signal" be over-laundered, unlike money?

Pretty much what is implied by the title. 

Credit to @sns who got me thinking about this. I've chosen a path of refrain. Others have chosen differently.

I'm curious about members' thoughts and experiences on this? 

Though this comes from a 'clocking thread' by no means am I restricting the topic to clocking alone.

Please consider my question from the perspective of all ["cleaning"] devices used in the digital chain, active and passive.

From member 'sns' and the Ethernet Clocking thread [for more context]:

"I recently experienced an issue of what I perceive as overclocking with addition of audiophile switch with OXCO clock.  Adding switch in front of server, NAS resulted in overly precise sound staging and images."

"My take is there can be an excessive amount of clocking within particular streaming setups.

...One can go [to0] far, based on my experience."

Acknowledgement and Request:

- For the bits are bits camp, the answer is obvious and given and I accept that.

- The OP is directed to those that have utilized devices in the signal path for "cleaning" purposes.

Note: I am using 'cleaning' as a broad and general catch-all term...it goes by many different names and approaches.

Thank You! - David.