Tvad, I'll take a stab at the vibration/top issue, by way of example. I have a CDP with case vibrations induced by the transformer. These vibrations are sufficient to rattle the tube innards which increases any potential they have to be microphonic. When I take the top off the CDP I'm eliminating one of the surfaces which facilitate the transmission of the vibrations. Often the audible (as well as physical) frequency (pitch if you will) and intensity of the vibration changes - usually lessens. Mass loading can have a similar effect.
If you have the best LN tubes and your unit has a low noise floor you might not actually change anything except reduce the audible transformer hum (not a bad thing at all), but if you have borderline tubes and a highish noise floor these vibrations can induce tube microphonics which can be audible. FWIW, I think there are better ways of getting 'spacious and open' than using microphonic tubes. :-)
If you have the best LN tubes and your unit has a low noise floor you might not actually change anything except reduce the audible transformer hum (not a bad thing at all), but if you have borderline tubes and a highish noise floor these vibrations can induce tube microphonics which can be audible. FWIW, I think there are better ways of getting 'spacious and open' than using microphonic tubes. :-)