Focal sopra 2/Gryphon Diablo 300 not good match

If you otherwise like the Focal house sound then this should be a great pairing.  What you are describing is an extreme version of my dislike for the Focal house sound - which I find thin, bright and all about detail.  Perhaps all that power from your Gryphon is accentuating these fatiguing aspects?

Are all the components fully broken in?
How did you arrive at this combination?  Did you audition everything beforehand?

try moving the speakers around before blaming the gear

Sounds like most Focal Speakers I have heard.  So now you have a decision.  Chase changes, modifications to your system to make them tolerable to you.

Or sell them to someone who loves the Focal Sound (and nothing wrong with that) and go find some speakers you love.

Otherwise... I'd be thinking Tube amp or pre-amp, or integrated.

Most of us here have had a speaker we just don't love.  Many of us (me included) have chased system changes to tolerate them and try to love them.  We post about the changes...

... but in the end most end up changing.  

Bummer. we've all been there.