Help with fatiguing sound in my PC system


I replaced my Halo Pre and Denon changer with a PS Audio DL III. I run lossless music into it from iTunes on a PC (Windows 7 64bit, core i7, 16MB RAM), I use a Pangea USB cable into a MF V-link, then go into the DAC with a Wireworld ultraviolet coax. The increased detail, clarity, resolution and extension are remarkable, but so is the amount of listening fatigue. The highs are too much, but the music sounds muffled if I add the pre-amp back. My system is profiled in the link below. I have some ideas, let the voting begin:
1 - buy an offramp or a pacecar (can't afford it!)
2 - use better USB/coax/interconnects/speaker cable
3 - apply acoustic treatments to the room
4 - use a software player (Jplay) that sits on top of iTunes
5 - buy speakers with different tweeters (Quad 22L2/Focal 826v, this is happening, but not any time soon)
6 - get a better amp (McCormack/Odyssey, distant future)
7 - tweak Windows 7/iTunes settings (WASAPI exclusive mode?!?)
8 - adjust speaker position/toe in (already did this and it helped a little)
I am thinking about trying #3/#7 next. Ideas? Thnx in advance.
realremo
agree, Davide256, I have placed my Halo pre back into the signal chain after purchasing the Jplay plugin. I did mess around with the volme control in the plugin, but 6dB steps don't do it for me. I am running the signal into the direct inputs on the Halo, this bypasses the tone control circuitry and goes straight to the volume pot. Still have to try it through the tone controls, see what that does. I'm having a ball though, headaches or not!
Also having the PS Audio DL III -- I would have to disagree with it as a cause for the fatiguing sound. I run from a SONOS digital coax out to the DLIII, to an AYRE integrated amplifier (vial XLR balanced ICs) to a pair of PSB Sync 1 speakers. The sound is warmer and gentler then my Ayre CDP in most cases. From the SONOS I am playing both my own Apple lossless files, and online music sources (XM, Pandora, etc...) I would just definately say that from SONOS to the DLIII with digital coax is a warm stronger source then my CDP.
Yes that is why I bought the DL III, for the warmth. I think I'm doing everything correctly, the synergy of my components is off, it'll take time to determine who the culprit is, might be a combination of things. it's frustrating.
sbleam, I wasn't saying that the dlink III is fatiguing when used as intended... just that it was fatiguing when fed direct to amp, no pre in between. As described you are using a pre amp section for the Dlink III analog output. And yup, listening fatigue is frustrating. I'd say about 75% of my music collection is now edge/fatigue free when played, and 24 bit music seems to make a big difference vs 16 bit. The remaining 25% of 44.1khz/16 bit music has me constantly tinkering with better caps, interconnects and considering a better DAC purchase next year.

Of course the way HDtracks is going, by next year I might be able to retire all my 16 bit music with 24 bit replacements (grin) and bypass a new DAC.
My ears won't stop ringing. I might have tinnitis. If so, I'm selling all my gear. The sound fatigue might have nothing to do with the jitter, the speakers or the amp, it might have everything to do with how loud I've listened to my music for the past 3 years.