How to run speaker wires...

I suppose you could tey whichever path you just mentioned and see for yourself.

I doubt seriously with todays cabling you'll experience much if any issues... PROVIDED you obtain decent wire/cable in the first place. Good cables will have the items concerning you already addressed in terms of inductance and dialectrics.

Unless you intend to go really cheap with the wire and/or wire gauge. IMHO

Twisted pair cabling for digital signals, such as CAT5e and other ethernet cabling, is twisted for three reasons. First, it results in reduced cross-talk between the pair of wires carrying the "transmit" signal (going from, say, device 1 to device 2), and the pair of wires carrying the "receive" signal (going from device 2 to device 1). Second, twisting provides better impedance control, to maintain waveform integrity. Third, it helps assure that interference pickup (rfi/emi) will be essentially equal between the + and - polarities of each signal, which will result in their rejection by the receiving device, which responds to the difference between + and -.

None of that has any relevance to speaker cables, though, due to the vastly lower frequencies that are involved, and also because the impedance levels are extremely low (which will tend to "short out" rfi/emi pickup, not to mention that a speaker will be unable to respond to anything at rfi/emi frequencies).

So I think that twisting would be pointless. As far as bundling + with + or + with -, I doubt that it will make any difference, and if it does I would imagine it would be cable dependent (specifically on dielectric thickness and type). So trying it both ways, as was suggested, is probably the only way to tell.

Regards,
-- Al