In any given instance - yes or no.
Assuming the price is listed out fairly, an offer of 80% is insulting.
Lets take a Nordost Quattro Fil cable of 1 meter - they usually sell for between $750 and $800 on Audiogon. Assume a listing price of $750, and an offer of $600 - that is ridiculous, and not worth a reply.
Of course, the seller takes a risk of never selling the product too!