Folks, everyone is talking resistance but there are two other factors that come into play. One is the inductance and capacitance of the cable, the other is the skin effect. For audio work, skin effect becomes a non issue when the wire is 16 g copper or thicker, and I doubt anyone reading this is using 20 or 18 g wire. The other is capacitance and inductance and these are tied together. If you are using dynamic loudspeakers, that is a speaker whose motor is a magnet with a voice coil and cone, then one needs very low inductance cable with the result of it being higher capacitance. The reason is inductance becomes a significant factor when the load impedance is low and most speakers have impedance dips below 8 Ohms and peaks above 8 Ohms. This causes an attenuation of signal if the cable is not low inductance. Plain zip cord is fairly inductive and thicker zip cord, that is the stuff with larger gauge copper, becomes even more inductive while the resistance drops. This is the reason speaker cables sound different. If you have a non dynamic speaker, that is a pure resistance load, i.e. Magnapan, ribbons, etc. or an electrostatic, then the parameters change. Resistive speakers require low resistance and a moderate inductance cable while electrostatic speakers are a special case but can more or less
live with higher inductance cables. There are other losses as well, but these variables are secondary to the above.
Regarding the question why no manufacturer will calculate the cable needed is a lot depends on the output impedance and phase margin of the amplifier. One just can't hang high capacitance on the output of an amp, it might cause it to oscillate. At the very least, it won't like the load; worst case is the amplifier dies a violent death. No cable manufacturer is going to take that risk, rather it is left up to the user to sort all this out.