For max sound quality per dollar I would highly recommend you consider an integrated amp, either Decware Zen Integrated
https://www.decware.com/newsite/SE34I.htm or if your budget allows Raven Blackhawk
https://www.decware.com/newsite/SE34I.htm I have the Blackhawk and highly recommend it.
Either of these amps relies on your using fairly efficient speakers. Either Tekton Double Impact or Moab will work, and well. I have Moab and have no doubt you will have both incredibly real solid draw you in sound with either of those amps and speaker combinations.
Given your room size and volume requirements, together with your desire for music quality, I would lean Decware and Double Impact and put the money "saved" on those into Townshend Podiums for the speakers and Pods for everything else. Then get your choice of great wire. Silversmith Fidelium are terrific for the money, or if you want warmer more natural Townshend F1 but they are quite a bit more, Fidelium are probably the high value bargain pick in wire.
Decware power conditioner. Your choice of source, I really have no opinion on digital.
Only other thing to add, in a situation like yours, quality over quantity, keep in mind that in general a system intelligently filled out with things like Podiums, Pods, HFT, fuses and other seeming accessory/tweaks will far outperform the same budget spent all on the big box components. A $4k speaker on $2k Podiums will sound much better than a $6k speaker on factory spikes. I have heard the difference. It is not even close.
A not insignificant factor, other than the Townshend (made in UK) all the rest of this is made here in the USA. Decware is lifetime warranty, and Raven might as well be. Synergistic and Silversmith made here as well. Decware, Raven and Tekton are all sold direct. This alone is huge. Everything sold through a dealer figure half the price evaporates as profit. You simply get more for your money from these manufacturers.