I haven't found cold, clinical, grainy or any combination of the above with Bryston. I've owned a B60 for a few years (SST no less), and have heard others countless times.
Bryston is very transparent. Transparent to the degree where many mistake the end sound with Bryston rather than looking upstream and downstream.
I've found systems with Bryston in them to be bright, dark, edgy, smooth, forward, laid-back, and everything else. What does that tell me? It's showing what it's fed.
Sounds like a BS answer to the original question, but I can't think of much of anything that'll not work well. It all depends on the sound you desire. The 4B will drive pretty much any speaker well from an electrical standpoint. It's a robust and stable amp. I'm sure there's some absurdly hard to drive speakers out there that'll make the 4B sweat a bit though.
Go on Audio Circle and ask James Tanner which speakers used Bryston in shows. That may give you a start. Thiel and Magnepan come to mind.
Bryston is very transparent. Transparent to the degree where many mistake the end sound with Bryston rather than looking upstream and downstream.
I've found systems with Bryston in them to be bright, dark, edgy, smooth, forward, laid-back, and everything else. What does that tell me? It's showing what it's fed.
Sounds like a BS answer to the original question, but I can't think of much of anything that'll not work well. It all depends on the sound you desire. The 4B will drive pretty much any speaker well from an electrical standpoint. It's a robust and stable amp. I'm sure there's some absurdly hard to drive speakers out there that'll make the 4B sweat a bit though.
Go on Audio Circle and ask James Tanner which speakers used Bryston in shows. That may give you a start. Thiel and Magnepan come to mind.