This sure was an old thread :)
As I "climbed" the ladder, I found myself not changing equipment nearly as often. First of all, it's too costly to change in this price category. Second of all, it's too heavy to move those big speakers and amps. Third, when I finally find good synergy, I am afraid to lose it.
So I have lived with BAT 75SE and SF Amati for years and just recently changed the amp to 150SE. I have tried a few other speakers since, SF Guarneri Memento, Usher BE-718, and almost bought MBL 116. Just sold the Usher because I was hitting my shipping quota, will most likely buy a pair back.
So no regret recently, until I buy the big Usher BE-20 and my wife forces me to sell the Amati, I am sure I will regret when it happens even though I love Usher BE-20.