Suggestions: Best speaker/sub combo for Desktop PC

Do you have to have a sub?... that is, will you use this more for music while working, or for watching movies?

For a small, consumer-oriented musical PC speaker, I've found the Klipsch ProMedia 2.0 hard to beat. (approx. $100 retail) They're vented out the back, but still sound a lot cleaner and tighter than any computer speaker costing twice as much at Best Buy or Fry's.

But if you really want to spend $400, you might go to a music equipment store, and check out some of the powered near-field monitors by M-Audio and similar manufacturers.

NHT MOO and SOO

I actually am a professional musician (orchestral and choral conductor), so music is my life's work and passion, so a sub is important in the equation to get full-range sound...this will not be for casual background listening, but critical imaging. I have a set of LSA 2 speakers that I power with an Arcam SOLO integrated amp...so that's what I'm used to hearing...but I'm looking for something that I can use on my PC to approximate full-range sounds when I can't sit in front of my towers....

Clay49,
Orbaudio.com "Classic One" setup with stereo pair, and subwoofer, fits the bill - $529 is not as cheap as Bose,
but when you check out the website,
your more professional/perfectionist need for truly fine miniature speaker computer sound may be better satisfied.
Are you using the computer for playback, and editing, of live digital recordings?

I am using for playback only for score study, and sometimes for pre-editing of recordings my choirs and orchestras have done...I don't do any editing outside of the studio and an SSL Console. I'll check out Orbaudio.com...thanks for the lead....