"Are you suggesting the use of a subwoofer with the OB1",
The OB1's have very good bass, but often extension is confused with output, and a transmission line is more about quality extension than absolute output. So adding a sub would simply add control and greater output for the last octave of sound. OB1's do not "need" a subwoofer but they will benefit from a subwoofer as almost any speaker would.
The Sophia has slightly bloated bass (WP7 too) to make it sound like it has deep bass robbing the bass of the unique timbre's of each instrument (to a degree, they are not Cerwin Vega's if you know what i mean)) . Do not be fooled by this. And let me say that it might take an OB1 experience to understand this statement fully.
Room construction can also dictate what kind of bass you will have.
"How much experience do you have with the OB1?"
Not a great deal, but enough to know that it is uniquely the real deal, an accurate loudspeaker. You better like your music because its not going to editorialize or boom or tizz or diffuse anything. It can handle modern solid state amplification so buy a good deal of power, because they will play extremely loud and you won't know it because the distortion is very low. Buying room treatments could be argued as essential with a speaker like this (ATC too.) because they will play 10dB louder than other speakers before you think they are the same volume as another speaker system. That extra energy needs somewhere to go.
Understand that accurate sometimes means forward (recordings fault) and won't give you a huge soundstage (if its not on the recording) but what it does mean is that instruments will sound very real and many of your marginal recordings will become very listenable.
"Can they be driven with a moderately powerful amp"
In your room, if you listen to light jazz and chamber music, you might get away with 100 watts, otherwise 200, high current, no tubes, minimum. This extra power is just to keep things clean on musical peaks, not too shatter your hearing with constant output.
As a Harbeth owner I think you will like these speakers, Harbeth quietly makes very accurate loudspeakers and the OB1 I think (my opinion) takes a step towards neutrality from the Harbeth sound, it very well may be a tweener sound between the ATC's and the Harbeth's.
So it would be worth a listen if you can get one. I like the speaker a great deal and it is not well known so don't look to the gallery for a great deal of back up. If you buy a pair you will be on your own till others get to hear what the speaker is capable of through you. Then they'll know why you bought them. :)