Over the years, I have tried multiple types of spikes (including Audiopoints) into the concrete floor beneath my 175 lb main speakers (inc. stands), and also under my two 160 lb subs (inc. stands). About a year or two ago, I removed the spikes and tried using damped springs beneath the speakers and subs, and I found the springs to be an improvement. Most recently, I have switched to using Herbie's Giant Fat Gliders both for convenience and stability, and I have not perceived any sonic detriment compared to using the springs.
After looking at this thread, I put the springs back under my speakers just for fun and found that I actually like the sound of the Herbie's Giant Fat Gliders better, I know...blasphemy, right? What would Max Townshend say? Springs, sorbothane, silicone, or Herbie's dBNeutralizer all provide some type of elastic damping and isolation. To me, the Herbie's products resulted in slightly fuller sounding body and better bass/dynamics, while the spring supported speakers sounded slightly thinner. The difference was noticeable but not substantial, and not as apparent as changing from spikes to springs. Maybe the differences I heard were the result of vibrational feedback or some slight distortion, but to me it doesn't really matter because it sounded better. FWIW, both the springs and the Herbie's products sat directly on commercial grade carpet over a dense commercial grade foam pad, over a concrete slab on grade. With either solution, over time the carpet and mat became quite compressed at the contact points. YMMV