I have a Windows 10 PC connected to a PS Audio DirectStream DAC via USB. I read about the possible improvement from isolating the ground on the USB connection to a DAC, got onto eBay and purchased a "USB Isolator with an ADUM4160 chip" (not an expensive one) and the results were slight but noticeable. I was pleasantly surprised to hear an improvement of the timbre from things like cymbals and violins, an improvement in the distinctness of low bass sounds (bass guitar, kick drum, etc) and a slight improvement in the placement of sounds in the soundstage.