While I have no doubt that in many setups the F5 would provide great sound (within its power range), the facts that it has a very wide specified 3db bandwidth of 1 MHz, a high input impedance of 100K, and uses feedback, raise some caution flags in my mind.
You've probably already seen it, but just to be sure I'll quote this paragraph from the manual:
A caveat is in order here this is a very wide band amplifier with a high input impedance. In order to prevent the output voltage from bleeding back to the input at very high frequencies (thus making a fine power oscillator), keep the input and output cables separate, and dont externally connect the speaker ground to the input ground. Good ground shielding on the input cables is important, and caution is called for in using Litz and other specially low inductance / high capacitance cables. I have not seen a specific example of a problem, but historically it is to be expected when an amplifiers bandwidth exceeds 200 KHz. If the amp makes funny noises, runs extra hot, or blows fuses, this might be an indicator of such an issue.
Also, I would be particularly cautious if the F5 would have to be placed close to a component containing significant amounts of digital circuitry, or if there is reason to suspect that you may be in a high RFI area (e.g., nearby radio stations), or if there is reason to suspect that your AC power is particularly noisy (e.g., nearby industrial plants).
Also, keeping speaker cables as short as possible would seem to be desirable, both to minimize capacitance and to minimize RFI pickup that may be injected into the amp's feedback loop.
Not sure how critical any of this is, but these kinds of things strike me as being potential sonic issues (or worse) with any very wide band high input impedance amp that uses feedback.
Regards,
-- Al