Fortunately, Don and I know where the "bad actors" are, and it’s no secret. Caps. Specifically, film caps. They’re the parts that need the 10 to 50 hour run-in. I do not like this ... it suggests the plastic film is undergoing a very slow chemical change while it is being charged, and a further change when the charge is modulated by an audio signal.
But direct-coupling is a whole another can of worms. The worst is that failures in one part of the amplifier cascade through the amplifier, and can even destroy loudspeakers. This is the typical failure mode of solid-state amplifiers ... a DC servo circuit, or voltage regulator, fails, and then destroys everything that is DC-connected to it. Cap-coupling or transformer coupling limits the failure to one part of the amplifier, and limits the scope of the failure to no more than a few parts.
Also, Don and I have prior experience and expectation to guide us when we try XYZ change. Is it audible at all? Is it better or worse, or just different? I don’t know about Don, but I can hear changes in ten seconds or less, and have a better, same, or worse reaction, or sort of a mixed feeling.
The mixed feeling is a danger sign and indicates that there’s something I don’t like but can’t describe or pin down. That’s pretty common at the serious design level, by the way. You often hear or feel things that just make you uneasy, which is a sign to turn it off immediately and take a good, hard look at the circuit and see what you missed. Maybe a wiring error. Look again. Stop, think, reflect, do something else. It happens to us all.
Yes, fresh film caps often sound dull, flat, and dynamically compressed. There are often subtler colorations I describe as "glossy" or softened, a kind of over-processed Photoshop impression. You hear it a few times, and you know it immediately.
But compared to an outright circuit error, that’s nothing. Those sound much worse, grainy, shrill, shouty, almost always something very very wrong, and almost always in the high frequencies. Does it sound "electronic"? Yeah, that’s bad. Find out what’s wrong. Look hard enough and you’ll find it.