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I have never found the PS Audio gear to be any good. I guess YMMV. I would also strongly suggest that any compression, including lossless, is not the route to good sound. I have also found that the cabling is critical to the sound you get.

check out Naim Audio's new HDX.

It sounded pretty darn good and was joy to use.

http://www.naim-audio.com/products/hdx.html

The Naim HDX looks pretty good eh?

If you don't want to wait for a lot of good one-box solutions to appear, you can go the PC (or Mac) audio route.

If you want more info on computer audio I suggest you check out the PC Audio forum here on Audigon. Most of the hundreds of threads Lush mentioned in his post are on that forum. You will find a great number of very worthwhile "prescriptive" solutions (such as the one Rbstehno just posted here), and you will also find a great deal of helpful background information.

Like good CDPs or good transports, computers (PC, Mac or Linux) can very good "PCM data handling machines" and as such are the least important part of a good digital audio system. As others have said, its the equipment upstream that is most important. IMO if you put enough research and money into those upstream components, you will have unrivaled sound quality.

The Memory Player by Nova Physics Group is your answer!