You are absolutely correct. Most speaker companies do just that. Purchase pretty good drivers and "stick um" in a MDF box. I would go for some space age cabinet material like Aluminum or Carbon Fiber. These and other composite materials will be the future of good speaker design. They hopefully will do away with the unwanted storage of the resonance that come hand in hand with MDF. Violins use plys of real wood for "wanted resonance". Vanderstein is experimenting with Carbon Fiber. Wilson benesch from England, not to be confused with Wilson Audio from Utah has been building speakers from Carbon Fiber for a number of years.
It seems like all I see in the industry is speaker companies coming out with new drivers made from all these different materials, ceramic, diamonds, titanium etc. They never really address the real problems of resonance. Planar speakers manage to eliminate lots of that because they just have a frame and not a storage box. I think that is why they
often sound so clear. I would not assume that these new drivers like the revelator are superior to the old, but tried and tested and user friendly, soft dome tweeters. Also I would start with a monitor speaker. Simple two way. Lots less cabinet to build. Someone once correctly stated "big speakers--big problems" The beauty there is you can build the monitor to sit on top of your bass drive when you get to that.
Good luck keep us informed.