" His new house has 8 in wall speakers distributed throughout the house."
8 mono speakers, 4 pair stereo. or 8 pair stereo?
"using the pre-outs from the Marantz"
Stereo or A/V, and if A/V, main preout or zone 2 preout?
Any way to control volume of individual rooms?
"Do the RCA splitters have any major negative effect?"
I would be more concerned about the speaker distribution box. Some have as much as a 50% power loss. Do you know the model number of this box?