Sounds like a tube may be ready to go bad. If the tube was already bad the amp should have blown the plate fuse which is indicated by the red light on the top of the amp chassis as mentioned above. You should try to isolate the problem quickly before the fuse blows. Once the fuse blows you will have to replace the fuse before swapping tubes around and then you must figure out which tube is going/has gone bad before the fuse blows again. I just went through this with my Premier 12s and at $15 a piece each time you have to replace a fuse it can add up very quickly.
BTW, I use the Premier 16 with my 12's....GREAT combo.
BTW, I use the Premier 16 with my 12's....GREAT combo.