Unfortunately, the ac compressor is going to infect the whole house, it won’t be confined to the subpanel. Running a 100 foot branch circuit makes it a magnet for EMI generated throughout the house, so I would use 3-wire romex. The wire is pre-twisted and helps with rejecting common mode noise, which could be a problem at that distance.So, I assume using 3 wire I would combine the two hots, giving me an effective gauge increase.
At this point I am only installing one outlet for my amp.