The minefield in most rooms is the below 100 Hz, if not the below 40 Hz area, where room modes are most likely to be excited. Since most floor standers cut out around this region, they are less likely to get into problems. So, less setup drama, but less bass extension.
Having a subwoofer that is well integrated to the ROOM first, and then the speakers however is like the gates of heaven. To get there Bass traps and DSP is usually required. The good news is that you can often avoid doing any DSP on your main speakers, and keep it all in subwoofer land, or use pre-DAC DSP units which are pretty cheap and very very good.
Best,
Erik