Go to Applications/Utilities/Audio MIDI Setup
You can set the bitrate and sample rate in there. I think the HDR is limited to 24 bit/96kHz (no 192kHz) and it is synchronous USB, so it isn't as good as a proper async USB connection.
One of the problems with the OSX audio API is that stays that way after you set it. Irrespective of the sample rate and bitrate of the files you are playing. Resampling sometimes isn't the best quality.
You can download a reasonably cheap app from the appstore called BitPerfect which allows iTunes to switch the sample rate on the fly. It does a fair bit of what more expensive apps like PureMusic, Amarra and Audirvana Plus does, such as loading the entire file into memory before playback etc.
I prefer Audirvana Plus because it supports DSD playback.