While the digital audio chain can certainly contribute fatigue, what I've personally found is that unbearable listening fatigue is more likely to come from the speakers, the amplifier, and the room.
If you are not planning to replace speakers and amplifiers for some time, then short term fix may be the room.
Does your room exhibit much in the way of slap echo?
If you are not planning to replace speakers and amplifiers for some time, then short term fix may be the room.
Does your room exhibit much in the way of slap echo?