Holes in back panel of speakers

If they penetrate all the way into the cabinet void they will have some affect on the sound, particularly if they are sealed (acoustic suspension) design. If they are ported, its less of a concern. Silicone is a good idea for a fix. I assume that you can tell the difference between a port (which typically is a flared plastic "vent" extending well into the cabinet, usually diameter on the order of inches, not 1/16ths. A ported speaker is also called a reflex or bass-reflex design.

Thanks for all the responses. Yes the holes are just small enough to screw holes in. The speakers are Paradigm Atom V.5 if that helps the reseller said the back panel is
made of thick wood and does not affect the sound.

I would just fill them in w wood putty or epoxy or silicone and "fuggedabowdit"

replace screws problem solved.