Mainly, I've moved which obviously implies new/different room acoustics. While it is indeed a 'variable change', now it's pretty much a constant (and I'll just have to work around it).
You've confirmed my belief that overall it's the speakers being the most important component. However, these same speakers provided good imaging before so I'm not sure it's them (unless they themselves are/have degraded over the past 5 or so years). I've tweeked/optimized the speaker placement, toe-in, levels, etc. and the best results are speakers that are approx 9 ft apart, with about a 30deg toe-in which focuses them on a 'sweet spot' at ear level about 12' in front. Since imaging has otherwise gone from being present to virtually non-existant makes me think there something else is the 'weak link' in the chain.
I'm going to take a good hard look at my interconnects & cabling. They've just 'sat there', sans any maintenance at all so it's likely they could use a good cleaning or maybe even replacement.
Beyond that, it could very well be that while attempting to upgrade my pre-amp, sources, etc. I may have indeed disrupted my overall 'system synergy'. Now, since overall component synergy is more 'by the grace of the gods' than formulaic, how to rectify.