Actually, pro-audio equipment (such as the Scarlett) typically have floating ground on their internal circuits. This requires special cable wiring on certain conditions such as a TRS-to-RCA cable where you actually have to disconnect the ground/shield wire from the RCA cable itself. See this link:
http://www.rane.com/note110.html
Many pre-made cables are not wired correctly here. I actually had to modify a Mogami RCA-to-TRS cable as well as a custom XLR-to-TRS cable to remove a ground loop hum issue when I used a Rane MLM82a stereo line mixer between my computer/dac and some powered monitors.