Issue with ARC Ref 110 amp

Obviously the amp should not blow fuses.  

Step 1:  Maybe the speakers are the problem.  Does the amp blow fuses if the speaker cables are disconnected from the amp's output taps?  Warning:  If you disconnect the speaker cables do NOT pass a signal to the amp.  Turn-on the mute button of your preamp.  You can damage tube amps with output trannies if there is no load on the outputs.

If the amp only blows fuses when hooked up to your speakers, maybe there is a short in the speakers. I assume you are using intact speaker cables.  

Step 2:  If speakers appear ok, did you check your tubes?  If the amp will not stay on, do you have a spare set of tubes, even old ones?  If yes, swap out the tubes for a spare set, at least the quad on the right side, to see if the problem persists.  Turn the bias down before turning the amp on.  

Step 3:  If the amp stays on do all tubes bias ok? If one or more tubes do not bias, the tube or tubes in question may have arc'ed and blown a bias resister. 

If all else fails, call ARC customer service and ask for Greg.  I hope this will not require a trip to the factory or ARC service center.     

Good luck.  The Ref 110 is a nice amp.  I am sure you will get your rig back up soon.

BIF

After the second time, I noticed that one of the speaker cables’ spades was broken 

This I think is your problem. Tube amps do not like to be run into an open circuit. If your spade broke and this opened the circuit that could do serious damage to your amp. Then again could be a red herring. You didn't mention the sound cutting out at all like it would do if the connection broke, and we don't know what you mean by "broke".  My guess would be that it cracked, but not enough to cut out completely just enough to make it sound bad and at the same time create an unstable load the amplifier couldn't handle, causing it to blow a fuse.

The Artesania thing is probably a misleading detail. Your amp has a lot of venting but the Artesania isn't anywhere near large enough to interfere with that, at least not the one I found on-line. 

It could also be that this is all coincidental, and it just happens that a tube decided to go bad at the same time as a spade broke and you are trying out a new tweak.

There are also resistors under the tubes and if you burned one of those out for any reason the amp won't run and will only blow fuses until those resistors are replaced.  

Thanks guys. After replacing speaker cables and moving IC cables to a different preamp input, the fuse doesn’t blow anymore but I can hear a subtle, high-pitch hiss on the right twitter. It’s not there all the time but comes and goes and starts to appear after a while, I guess when the amp starts to heat. Any idea?