Listening fatigue

This may be low-brow for Audiogon folks due to the nature of the gear, but here goes: I have a pair of Totem Mites driven by an NAD 326BEE, with an NAD 345BEE disc player and a Velodyne SPL-800 in my master bedroom (carpeted, basically about 15X20 with a small entry hall). The problem is fatigue – if the volume goes up, it gets to be too much very quickly. I've tried different speaker locations and padding on the first points of reflection, but it hasn't helped much. I'm using 12 gauge wire, but would an upgrade here help? Or is it an unfortunate component combo? Any suggestions would be appreciated ... thanks.